2881017-49-6
Chemical Structure
Blixeprodil
Synonym(s): GM-1020
- CAS No.: 2881017-49-6
- Formula:C13H16FNO
- Molecular Weight:221.27
InChIKey: GLHWPYBETIKGHM-CYBMUJFWSA-N
SMILES: CN[C@]1(C2=CC=C(C=C2)F)C(CCCC1)=O
Biological Activity: Blixeprodil (GM-1020) is an orally active, blood-brain barrier-penetrant NMDA receptor inhibitor with a Ki of 3.25 µM in rat cortical tissues. Blixeprodil binds to the MK-801 ion channel site and blocks NMDA receptor-mediated currents in hyperpolarized states in a voltage-dependent manner. Blixeprodil modulates the power of cortical EEG frequency bands, alters spontaneous motor activity, and induces ataxia at high doses. Blixeprodil can be used in the research of depression[1].
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Blixeprodil | Blixeprodil (GM-1020) is an orally active, blood-brain barrier-penetrant NMDA receptor inhibitor with a Ki of 3.25 µM in rat cortical tissues. Blixeprodil binds to the MK-801 ion channel site and blocks NMDA receptor-mediated currents in hyperpolarized states in a voltage-dependent manner. Blixeprodil modulates the power of cortical EEG frequency bands, alters spontaneous motor activity, and induces ataxia at high doses. Blixeprodil can be used in the research of depression. | |||||||||||||||||||||
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Keywords
