29091-05-2
Chemical Structure
Dinitramine
- CAS No.: 29091-05-2
- Formula:C11H13F3N4O4
- Molecular Weight:322.24
IUPAC Name: N1,N1-diethyl-2,6-dinitro-4-(trifluoromethyl)benzene-1,3-diamine
InChIKey: OFDYMSKSGFSLLM-UHFFFAOYSA-N
SMILES: NC1=C([N+]([O-])=O)C(N(CC)CC)=C(C=C1C(F)(F)F)[N+]([O-])=O
Biological Activity: Dinitramine is a herbicide. Dinitramine activates the Erk/P38/JNK/MAPK pathway and inactivates the PI3k/Akt pathway in testicular cells. Dinitramine induces endoplasmic reticulum stress, dysregulation of calcium homeostasis in the cytoplasm and mitochondria, apoptosis, and downregulated expression of cell cycle genes in testicular cells. Dinitramine reduces the viability and proliferation capacity of testicular cells, and inhibits cell division by suppressing the synthesis of tubulin. Dinitramine induces abnormal heart development, inhibited angiogenesis, inflammatory responses, apoptosis, and impaired embryonic growth in zebrafish embryos[1][2].
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Dinitramine | Dinitramine is a herbicide. Dinitramine activates the Erk/P38/JNK/MAPK pathway and inactivates the PI3k/Akt pathway in testicular cells. Dinitramine induces endoplasmic reticulum stress, dysregulation of calcium homeostasis in the cytoplasm and mitochondria, apoptosis, and downregulated expression of cell cycle genes in testicular cells. Dinitramine reduces the viability and proliferation capacity of testicular cells, and inhibits cell division by suppressing the synthesis of tubulin. Dinitramine induces abnormal heart development, inhibited angiogenesis, inflammatory responses, apoptosis, and impaired embryonic growth in zebrafish embryos. | |||||||||||||||||||||
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- [1]. Ham J, et al. The herbicide dinitramine affects the proliferation of murine testicular cells via endoplasmic reticulum stress-induced calcium dysregulation. Environ Pollut. 2021;272:115982. [Content Brief]
- [2]. Park H, et al. Dinitramine induces cardiotoxicity and morphological alterations on zebrafish embryo development. Aquat Toxicol. 2021;240:105982. [Content Brief]
Keywords
