2912-11-0
Chemical Structure
Affinisine
- CAS No.: 2912-11-0
- Formula:C20H24N2O
- Molecular Weight:308.42
IUPAC Name: ((6S,7R,10R,11R,11aS,E)-9-ethylidene-5-methyl-5,6,8,9,10,11,11a,12-octahydro-6,10-methanoindolo[3,2-b]quinolizin-11-yl)methanol
InChIKey: UVWQYWHKTZABSO-ILADVTTDSA-N
SMILES: CN1C2=C(C3=CC=CC=C31)C[C@]4([H])[N@@]5[C@@]2([H])C[C@](/C(C5)=C\C)([H])[C@H]4CO
Biological Activity: Affinisine is an indole alkaloid present in Alstonia macrophylla and Tabernaemontana catharinensis. Affinisine induces apoptosis, cell cycle arrest and reduces cell viability in melanoma cells. Affinisine can be used in studies related to cancers such as melanoma, glioma and breast cancer[1][2][3].
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Affinisine | Affinisine is an indole alkaloid present in Alstonia macrophylla and Tabernaemontana catharinensis. Affinisine induces apoptosis, cell cycle arrest and reduces cell viability in melanoma cells. Affinisine can be used in studies related to cancers such as melanoma, glioma and breast cancer. | |||||||||||||||||||||
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References
- [1]. Lim SH, et al. Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia macrophylla. Phytochemistry. 2014 Feb;98:204-15.
- [2]. Fagundes Rosales P, et al. Extraction, isolation and in vitro evaluation of affinisine from Tabernaemontana catharinensis in human melanoma cells. Bioorganic chemistry. 2019 Sep;90:103079.
- [3]. Reis FL, et al. In vitro antiproliferative activity of alkaloids isolated from Tabernaemontana catharinensis A.DC (Apocynaceae). Nat Prod Res. 2022 Nov;36(22):5808-5812.
