2918281-79-3
Chemical Structure
RET-IN-22
- CAS No.: 2918281-79-3
- Formula:C29H31F3N6O4
- Molecular Weight:584.59
IUPAC Name: 1-(4-(5-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazol-3-yl)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
InChIKey: KVGTWUGUDPNRGC-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C2=NNC(C3=CC=C(OCCN4CCOCC4)C=C3)=C2)C=C1)NC5=NOC(C(C)(C(F)(F)F)C)=C5
Biological Activity: RET-IN-22 (compound 17b) is a potent, selective and orally active RET inhibitor with an IC50 of 20.9 nM and 18.3 nM for wild-type RET and RET-V804M, respectively. RET-IN-22 shows highly selective profile to most kinases, especially to EGFR and VEGFR2. RET-IN-22 has anticancer effects[1].
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RET-IN-22 | RET-IN-22 (compound 17b) is a potent, selective and orally active RET inhibitor with an IC50 of 20.9 nM and 18.3 nM for wild-type RET and RET-V804M, respectively. RET-IN-22 shows highly selective profile to most kinases, especially to EGFR and VEGFR2. RET-IN-22 has anticancer effects. | |||||||||||||||||||||
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Keywords
