2921944-77-4
2921944-77-4
Chemical Structure
UCM-13369
- CAS No.: 2921944-77-4
- Formula:C25H31N3O
- Molecular Weight:389.53
InChIKey: OTZVSBFNXXVEAU-OTPAQWSUSA-N
SMILES: N[C@@H]([C@@H]1CCNCC2CC2)[C@@H](C3=CC=C(OC)C=C3)CC4=C1C5=C(N4)C=CC=C5
Biological Activity: UCM-13369 (Compound 4b) is a NPM1 inhibitor. UCM-13369 downregulates the pathway associated with mutant NPM1 C+, and specifically recognizes the C-end DNA-binding domain of NPM1 C+. UCM-13369 induces apoptosis in AML cell lines and primary cells, that can be used for the research of AML[1].
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UCM-13369 | UCM-13369 (Compound 4b) is a NPM1 inhibitor. UCM-13369 downregulates the pathway associated with mutant NPM1 C+, and specifically recognizes the C-end DNA-binding domain of NPM1 C+. UCM-13369 induces apoptosis in AML cell lines and primary cells, that can be used for the research of AML. | |||||||||||||||||||||
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References
Keywords
