2923365-71-1
Chemical Structure
CH7233163
- CAS No.: 2923365-71-1
- Formula:C31H34F3N9O3S
- Molecular Weight:669.72
IUPAC Name: N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-5-isopropyl-7-(4-methylpiperazin-1-yl)-9-(2,2,2-trifluoroethoxy)-5H-pyrido[4,3-b]indol-3-amine
InChIKey: KMBMYNDPNVGEFI-UHFFFAOYSA-N
SMILES: CN(CC1)CCN1C2=CC3=C(C(OCC(F)(F)F)=C2)C4=CN=C(NC5=CC=NC(C6=CN(S(=O)(C7CC7)=O)N=C6)=N5)C=C4N3C(C)C
Biological Activity: CH7233163 is a noncovalent ATP-competitive inhibitor for EGFR-Del19/T790M/C797S. CH7233163 can overcome Osimertinib (HY-15772)-Resistant EGFR-Del19/T790M/C797S mutation. CH7233163 blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 has antitumor activities[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CH7233163 | 99.41% | CH7233163 is a noncovalent ATP-competitive inhibitor for EGFR-Del19/T790M/C797S. CH7233163 can overcome Osimertinib (HY-15772)-Resistant EGFR-Del19/T790M/C797S mutation. CH7233163 blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 has antitumor activities. | ||||||||||||||||||||
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Keywords
