2941386-44-1
Chemical Structure
Anle138b-F105
- CAS No.: 2941386-44-1
- Formula:C36H37FN4O5
- Molecular Weight:624.70
InChIKey: MEIDEMYMCHHCAT-UHFFFAOYSA-N
SMILES: FC(C=C1)=CC=C1COC2=CC=CC(CNCCOCCOCCNC3=CC(C4=CC(C5=CC=C(OCO6)C6=C5)=NN4)=CC=C3)=C2
Biological Activity: Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) that targets p62/Sequestosome-1/SQSTM1. Anle138b-F105 binds to the ZZ domain of p62, induces conformational activation, self-oligomerization, interaction with LC3, and formation of autophagosomes. Anle138b-F105 induces autophagic flux of ubiquitin-conjugated aggregated proteins, leading to their lysosomal degradation. Anle138b-F105 is applicable for the research of neurodegenerative proteinopathies[1].
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Anle138b-F105 | 98.18% | Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) that targets p62/Sequestosome-1/SQSTM1. Anle138b-F105 binds to the ZZ domain of p62, induces conformational activation, self-oligomerization, interaction with LC3, and formation of autophagosomes. Anle138b-F105 induces autophagic flux of ubiquitin-conjugated aggregated proteins, leading to their lysosomal degradation. Anle138b-F105 is applicable for the research of neurodegenerative proteinopathies. | ||||||||||||||||||||
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