2986688-90-6
Chemical Structure
CB1/2 agonist 1
- CAS No.: 2986688-90-6
- Formula:C21H24BrFN2O2
- Molecular Weight:435.33
IUPAC Name: 5-bromo-N-cycloheptyl-1-(4-fluorobenzyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
InChIKey: IBDOGMBSQPMZKN-UHFFFAOYSA-N
SMILES: CC1=C(C=C(C(N1CC2=CC=C(C=C2)F)=O)C(NC3CCCCCC3)=O)Br
Biological Activity: CB1/2 agonist 1 is a potent and cross the blood-brain barrier CB1/2 agonist with EC50s of 56.15, 11.63 nM for CB1R and CB2R, respectively. CB1/2 agonist 1 reduces glutamate release and LPS-induced activation of microglial cells. CB1/2 agonist 1 shows anti-inflammatory and antinociceptive effects. CB1/2 agonist 1 has the potential for the research of multiple sclerosis[1].
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CB1/2 agonist 1 | 98.68% | CB1/2 agonist 1 is a potent and cross the blood-brain barrier CB1/2 agonist with EC50s of 56.15, 11.63 nM for CB1R and CB2R, respectively. CB1/2 agonist 1 reduces glutamate release and LPS-induced activation of microglial cells. CB1/2 agonist 1 shows anti-inflammatory and antinociceptive effects. CB1/2 agonist 1 has the potential for the research of multiple sclerosis. | ||||||||||||||||||||
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Keywords
