2991054-23-8
2991054-23-8
Chemical Structure
FLT3/CHK1-IN-1
- CAS No.: 2991054-23-8
- Formula:C25H33F3N6O2
- Molecular Weight:506.56
InChIKey: LHDKPFSHXFFALR-HDICACEKSA-N
SMILES: N[C@H]1CC[C@@H](NC2=NC(NC3=CC4=C(C=C3)CN(C(CC(O)(C)C)=O)CC4)=NC=C2C(F)(F)F)CC1
Biological Activity: FLT3/CHK-IN-1 (Compound 18) is a dual inhibitor of FLT3/CHK1. FLT3/CHK-IN-1 is more than 1700 times more selective to c-KI T and greatly reduces hERG affinity with an IC50 value of 58.4 μM. FLT3/CHK-IN-1 inhibits tumor growth in mouse xenotransplantation models inoculated with MV-4-11 cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FLT3/CHK1-IN-1 | 99.37% | FLT3/CHK-IN-1 (Compound 18) is a dual inhibitor of FLT3/CHK1. FLT3/CHK-IN-1 is more than 1700 times more selective to c-KI T and greatly reduces hERG affinity with an IC50 value of 58.4 μM. FLT3/CHK-IN-1 inhibits tumor growth in mouse xenotransplantation models inoculated with MV-4-11 cells. | ||||||||||||||||||||
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References
Keywords
