2998928-68-8
Chemical Structure
Os30
- CAS No.: 2998928-68-8
- Formula:C27H33N7O2S
- Molecular Weight:519.66
InChIKey: QBVWTVAJGQIBKK-UHFFFAOYSA-N
SMILES: CN(C1=C2C=CC=C1)C=C2C3=CC=NC(NC4=CC(NS(C)(=O)=O)=C(N5CCC(N(C)C)CC5)C=C4)=N3
Biological Activity: Os30, a potent fourth-generation EGFR inhibitor, is a potent EGFRC797S-TK inhibitor with IC50 values of 18 nM and 113 nM for EGFRDel19/T790M/C797S TK and EGFRL858R/T790M/C797S TK, respectively. Os30 can suppress EGFR phosphorylation, arrest at G1 phase and induce the apoptosis of KC-0116 (BaF3-EGFRDel19/T790M/C797S) cells. Os30 shows potent antitumor efficacy on non-small cell lung cancer (NSCLC) with EGFmRC797S mutation[1].
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Os30 | 98.34% | Os30, a potent fourth-generation EGFR inhibitor, is a potent EGFRC797S-TK inhibitor with IC50 values of 18 nM and 113 nM for EGFRDel19/T790M/C797S TK and EGFRL858R/T790M/C797S TK, respectively. Os30 can suppress EGFR phosphorylation, arrest at G1 phase and induce the apoptosis of KC-0116 (BaF3-EGFRDel19/T790M/C797S) cells. Os30 shows potent antitumor efficacy on non-small cell lung cancer (NSCLC) with EGFmRC797S mutation. | ||||||||||||||||||||
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Keywords
