3003751-14-9
3003751-14-9
Chemical Structure
hCYP3A4-IN-1
- CAS No.: 3003751-14-9
- Formula:C20H18N2O
- Molecular Weight:302.37
InChIKey: GJMNSVINGWNJFM-ONNFQVAWSA-N
SMILES: CN(C)C1=CC=C(C(/C=C/C2=CC(C=CN=C3)=C3C=C2)=O)C=C1
Biological Activity: hCYP3A4-IN-1 (compound C6) is a potent, orally active hCYP3A4 inhibitor. hCYP3A4-IN-1 shows the IC50 values of 43.93 nM and 153.00 nM against hCYP3A4 in human liver microsomes (HLMs) and CHO-3A4 stably transfected cell line, respectively. hCYP3A4-IN-1 potently inhibits CYP3A4-catalyzed N-ethyl-1,8-naphthalimide (NEN) hydroxylation in a competitive manner (Ki = 30.00 nM)[1].
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hCYP3A4-IN-1 | hCYP3A4-IN-1 (compound C6) is a potent, orally active hCYP3A4 inhibitor. hCYP3A4-IN-1 shows the IC50 values of 43.93 nM and 153.00 nM against hCYP3A4 in human liver microsomes (HLMs) and CHO-3A4 stably transfected cell line, respectively. hCYP3A4-IN-1 potently inhibits CYP3A4-catalyzed N-ethyl-1,8-naphthalimide (NEN) hydroxylation in a competitive manner (Ki = 30.00 nM). | |||||||||||||||||||||
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