3020765-70-9
Chemical Structure
(S,S)-SARM1-IN-9
- CAS No.: 3020765-70-9
- Formula:C25H21N3O4
- Molecular Weight:427.45
InChIKey: XQZWDWZQJWRUAA-CYFREDJKSA-N
SMILES: C=CC(N1[C@@H](C2=CC=C(OCO3)C3=C2)C4=C(C[C@H]1C(NCC#C)=O)C5=CC=CC=C5N4)=O
Biological Activity: (S,S)-SARM1-IN-9 (Compound MY-13A) is a stereoselective SARM1 inhibitor with covalent binding properties. (S,S)-SARM1-IN-9 covalently modifies Cys311 in the autoregulatory ARM domain of wild-type SARM1, thereby blocking NADase activity, without inhibiting the SARM1C311A or SARM1C311S mutants. (S,S)-SARM1-IN-9 blocks vacor- and vincristine-induced axon degeneration in primary rodent dorsal root ganglion neurons. (S,S)-SARM1-IN-9 can be used for research on axon degeneration-dependent neurological disorders, including chemotherapy-induced peripheral neuropathy[1].
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(S,S)-SARM1-IN-9 | 99.67% | (S,S)-SARM1-IN-9 (Compound MY-13A) is a stereoselective SARM1 inhibitor with covalent binding properties. (S,S)-SARM1-IN-9 covalently modifies Cys311 in the autoregulatory ARM domain of wild-type SARM1, thereby blocking NADase activity, without inhibiting the SARM1C311A or SARM1C311S mutants. (S,S)-SARM1-IN-9 blocks vacor- and vincristine-induced axon degeneration in primary rodent dorsal root ganglion neurons. (S,S)-SARM1-IN-9 can be used for research on axon degeneration-dependent neurological disorders, including chemotherapy-induced peripheral neuropathy. | ||||||||||||||||||||
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Keywords
