302343-04-0
Chemical Structure
Aurein 2.2
- CAS No.: 302343-04-0
- Formula:C76H131N19O19
- Molecular Weight:1614.97
InChIKey: RHKXKZPHWWEIOV-UJOXCNDQSA-N
SMILES: CC(C)C[C@@H](C(N)=O)NC([C@H](CO)NC(CNC([C@H](CC(C)C)NC([C@H](C)NC(CNC([C@H](C(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CC(C)C)NC(CN)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Aurein 2.2 is a major component of the skin secretion of L.aurea. Aurein 2.2 is an antibiotic with broad-spectrum antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and S. epidermidis[1][2].
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Aurein 2.2 | Aurein 2.2 is a major component of the skin secretion of L.aurea. Aurein 2.2 is an antibiotic with broad-spectrum antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and S. epidermidis. | |||||||||||||||||||||
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- [1]. Rozek T, et al. The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2. Eur J Biochem. 2000 Sep;267(17):5330-41. [Content Brief]
- [2]. Raheem N, et al. Insights into the mechanism of action of two analogues of aurein 2.2. Biochim Biophys Acta Biomembr. 2020 Jun 1;1862(6):183262. [Content Brief]
Keywords
