302343-11-9
Chemical Structure
Aurein 3.1
- CAS No.: 302343-11-9
- Formula:C81H136N22O20
- Molecular Weight:1738.08
InChIKey: NVLUQRRSHVBFHI-PXGMBHJKSA-N
SMILES: CC[C@H](C)[C@@H](C(N)=O)NC([C@H](CO)NC(CNC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CC1=CN=CN1)NC(CNC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CC(C)C)NC(CN)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Aurein 3.1 is an antibiotic antimicrobial peptide. Aurein 2.6 is active against Gram-positive bacterial (MIC: 80, 50, 50, 50, 50 μM for M. luteus, S. aureus, S. epidermis, S. mutans, B. subtilis)[1][2].
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Aurein 3.1 | Aurein 3.1 is an antibiotic antimicrobial peptide. Aurein 2.6 is active against Gram-positive bacterial (MIC: 80, 50, 50, 50, 50 μM for M. luteus, S. aureus, S. epidermis, S. mutans, B. subtilis). | |||||||||||||||||||||
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- [1]. Rozek T, et al. The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2. Eur J Biochem. 2000 Sep;267(17):5330-41. [Content Brief]
- [2]. Dennison SR, et al. PEGylation enhances the antibacterial and therapeutic potential of amphibian host defence peptides. Biochim Biophys Acta Biomembr. 2022 Feb 1;1864(1):183806. [Content Brief]
Keywords
