3024909-61-0
3024909-61-0
Chemical Structure
GSPT1 degrader-10
- CAS. Nr.: 3024909-61-0
- Formula:C38H38ClN7O5
- Molecular Weight:708.21
InChIKey: RQRVDLHEZAZZNS-UHFFFAOYSA-N
SMILES: O=C1NC(C(CC1)N2C(C3=CC=C(N4CCC(CC4)CN5C(N(CCC5)C6=CC(C7=C(Cl)C8=C(NC=C8CC)N=C7)=CC=C6)=O)C=C3C2=O)=O)=O
Biological Activity: GSPT1 degrader-10 (compound A) is a cereblon-based molecular glue degrader of GSPT1 with more than 95% degradation. GSPT1 degrader-8 inhibits cell viability in HL-60 cells with an IC50 of 10 nM[1].
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GSPT1 degrader-10 | GSPT1 degrader-10 (compound A) is a cereblon-based molecular glue degrader of GSPT1 with more than 95% degradation. GSPT1 degrader-8 inhibits cell viability in HL-60 cells with an IC50 of 10 nM. | |||||||||||||||||||||
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