3025082-14-5
3025082-14-5
Chemical Structure
PROTAC CDK4/6 degrader 1
- CAS No.: 3025082-14-5
- Formula:C41H47N11O6
- Molecular Weight:789.88
InChIKey: ITSRILWBOAUMKU-UHFFFAOYSA-N
SMILES: O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CCCCC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)=NC=C2N=C1)C8CCCC8
Biological Activity: PROTAC CDK4/6 degrader 1 is a CDK4/CDK6 PROTAC degrader, with DC50 values of 10.5 nM and 2.5 nM, respectively. PROTAC CDK4/6 degrader 1 inhibits the proliferation of Jurkat cells (IC50 = 0.18 μM), arrests the cell cycle at the G1 phase, and induces apoptosis. PROTAC CDK4/6 degrader 1 can be used for cancer research.
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PROTAC CDK4/6 degrader 1 | 98.88% | PROTAC CDK4/6 degrader 1 is a CDK4/CDK6 PROTAC degrader, with DC50 values of 10.5 nM and 2.5 nM, respectively. PROTAC CDK4/6 degrader 1 inhibits the proliferation of Jurkat cells (IC50 = 0.18 μM), arrests the cell cycle at the G1 phase, and induces apoptosis. PROTAC CDK4/6 degrader 1 can be used for cancer research. | ||||||||||||||||||||
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Keywords
