30275-80-0
Chemical Structure
6-Bnz-cAMP
Synonym(s): N6-Benzoyl-cAMP
- CAS No.: 30275-80-0
- Formula:C17H16N5O7P
- Molecular Weight:433.31
IUPAC Name: N-(9-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-9H-purin-6-yl)benzamide
InChIKey: NXYCBMGKNCJXIC-CNEMSGBDSA-N
SMILES: O[C@@H]1[C@H](OP2(O)=O)[C@@H](CO2)O[C@H]1N3C=NC4=C3N=CN=C4NC(C5=CC=CC=C5)=O
Biological Activity: 6-Bnz-cAMP, a derivative of cyclic adenosine monophosphate (cAMP), is a selective PKA activator with inhibitory activity against the bTREK-1 K+ channel. 6-Bnz-cAMP does not activate the Epac signaling pathway. 6-Bnz-cAMP inhibits the bTREK-1 K+ channel via a voltage-independent, ATP-dependent mechanism that is independent of the PKA/Epac/calmodulin kinase/MAP kinase pathway. 6-Bnz-cAMP activates CREB phosphorylation to regulate osteoblast-specific gene expression, induces osteoblast differentiation, promotes extracellular matrix mineralization, supports osteoblast proliferation, and shows no cytotoxicity toward osteoblasts. 6-Bnz-cAMP can be used in studies related to bone tissue repair and regeneration[1][2][3].
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6-Bnz-cAMP | 6-Bnz-cAMP, a derivative of cyclic adenosine monophosphate (cAMP), is a selective PKA activator with inhibitory activity against the bTREK-1 K+ channel. 6-Bnz-cAMP does not activate the Epac signaling pathway. 6-Bnz-cAMP inhibits the bTREK-1 K+ channel via a voltage-independent, ATP-dependent mechanism that is independent of the PKA/Epac/calmodulin kinase/MAP kinase pathway. 6-Bnz-cAMP activates CREB phosphorylation to regulate osteoblast-specific gene expression, induces osteoblast differentiation, promotes extracellular matrix mineralization, supports osteoblast proliferation, and shows no cytotoxicity toward osteoblasts. 6-Bnz-cAMP can be used in studies related to bone tissue repair and regeneration. | |||||||||||||||||||||
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- [1]. Hayashi M, et al. Actions of cAMP on calcium sensitization in human detrusor smooth muscle contraction. BJU Int. 2016;117(1):179-191. [Content Brief]
- [2]. Liu H, et al. N6-substituted cAMP analogs inhibit bTREK-1 K+ channels and stimulate cortisol secretion by a protein kinase A-independent mechanism[J]. Molecular pharmacology, 2009, 76(6): 1290-1301. [Content Brief]
- [3]. Lo KW, et al. The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization. J Tissue Eng Regen Med. 2012;6(1):40-48. [Content Brief]
Keywords
