3027905-74-1
3027905-74-1
Chemical Structure
Antitumor agent-172
- CAS No.: 3027905-74-1
- Formula:C37H50N8O4
- Molecular Weight:670.84
InChIKey: PTWAMJRFMLXZPR-IDCGIGBZSA-N
SMILES: O=C(C(C)(OC1=CC(N2CCC[C@H](C2)NC(N(CC3=CC=C(C=C3)C4=CNN=C4)C5CC5)=O)=CC=C1)C)NCC(N6CCCC6CCN)=O
Biological Activity: Antitumor agent-172 (Compound 28) is an inhibitor for β-catenin/BCL9 interaction with IC50 of 3.92 μM. Antitumor agent-172 exhibits high affinity to β-catenin with Kd of 82 nM. Antitumor agent-172 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Antitumor agent-172 | 98.51% | Antitumor agent-172 (Compound 28) is an inhibitor for β-catenin/BCL9 interaction with IC50 of 3.92 μM. Antitumor agent-172 exhibits high affinity to β-catenin with Kd of 82 nM. Antitumor agent-172 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models. | ||||||||||||||||||||
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References
Keywords
