3029090-15-8
3029090-15-8
Chemical Structure
N-Deschlorobenzoyl indomethacin-d3
- CAS No.: 3029090-15-8
- Formula:C12H10D3NO3
- Molecular Weight:222.26
InChIKey: TXWGINUZLBAKDF-BMSJAHLVSA-N
SMILES: CC(NC1=C2C=C(OC([2H])([2H])[2H])C=C1)=C2CC(O)=O
Biological Activity: N-Deschlorobenzoyl indomethacin-d3 is the deuterium labeled N-Deschlorobenzoyl indomethacin (HY-W008567). N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity[1].
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N-Deschlorobenzoyl indomethacin-d3 | N-Deschlorobenzoyl indomethacin-d3 is the deuterium labeled N-Deschlorobenzoyl indomethacin (HY-W008567). N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity. | |||||||||||||||||||||
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N-Deschlorobenzoyl indomethacin | 95.0% | N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity. | ||||||||||||||||||||
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