3029700-80-6
Chemical Structure
JF629-HTL
- CAS. Nr.: 3029700-80-6
- Formula:C41H46ClN5O5Si
- Molecular Weight:752.37
InChIKey: PYNYMIKZVQVKOB-UHFFFAOYSA-N
SMILES: C[Si]1(C2=CC(N3CC(C3)C#N)=CC=C2C4(C5=CC=C(C=C51)N6CC(C6)C#N)OC(C7=CC=C(C=C74)C(NCCOCCOCCCCCCCl)=O)=O)C
Biological Activity: JF629-HTL is a far-red fluorogenic HaloTag ligand. Binding of JF629-HTL to HaloTag protein alters the local environment of the dye, promoting the transition of rhodamine from a non-fluorescent state to a fluorescent state, thereby generating a fluorescence enhancement signal. In the light-controlled psHaloTag system, JF629-HTL shows a 6.7-fold fluorescence enhancement after irradiation at 450 nm. JF629-HTL serves as a research tool for far-red fluorescence imaging and the development of chemogenetic biosensors[1][2][3].
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JF629-HTL | JF629-HTL is a far-red fluorogenic HaloTag ligand. Binding of JF629-HTL to HaloTag protein alters the local environment of the dye, promoting the transition of rhodamine from a non-fluorescent state to a fluorescent state, thereby generating a fluorescence enhancement signal. In the light-controlled psHaloTag system, JF629-HTL shows a 6.7-fold fluorescence enhancement after irradiation at 450 nm. JF629-HTL serves as a research tool for far-red fluorescence imaging and the development of chemogenetic biosensors. | |||||||||||||||||||||
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References
- [1]. Walterspiel F, et al. A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells. Angewandte Chemie (International ed. in English). 2025 Dec 08;64(50):e202424955. [Content Brief]
- [2]. Deo C, et al. Bright and tunable far-red chemigenetic indicators. bioRxiv. 2020.
- [3]. Mehta S, et al. Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors. bioRxiv. 2026.
