3030279-55-8
Chemical Structure
PROTAC CDK2 Degrader-2
- CAS No.: 3030279-55-8
- Formula:C39H46F6N8O5S
- Molecular Weight:852.89
IUPAC Name: N-((3S,4R)-1-((1-(4-(2,6-dioxopiperidin-3-yl)-2-fluorophenyl)piperidin-4-yl)methyl)-3-fluoropiperidin-4-yl)-3-fluoro-4-((4-((S)-3-hydroxy-3-methylpiperidin-1-yl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzenesulfonamide
InChIKey: MQWDHROLFNTJMK-PONYFJNFSA-N
SMILES: O=S(C1=CC=C(NC2=NC=C(C(F)(F)F)C(N3C[C@@](C)(O)CCC3)=N2)C(F)=C1)(N[C@H]4[C@@H](F)CN(CC5CCN(C6=CC=C(C(CC7)C(NC7=O)=O)C=C6F)CC5)CC4)=O
Biological Activity: PROTAC CDK2 Degrader-2 is an orally active CDK2 PROTAC degrader, with DC50 values of 13 nM (MKN1cells) and 17 nM (TOV21G cells). PROTAC CDK2 Degrader-2 induces G1 phase arrest in MKN1 cells. PROTAC CDK2 Degrader-2 achieves tumor stasis in HCC1569 (CCNE1-amplified) xenograft models. PROTAC CDK2 Degrader-2 can be used for the study of CCNE1-amplified cancers[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PROTAC CDK2 Degrader-2 | 99.51% | PROTAC CDK2 Degrader-2 is an orally active CDK2 PROTAC degrader, with DC50 values of 13 nM (MKN1cells) and 17 nM (TOV21G cells). PROTAC CDK2 Degrader-2 induces G1 phase arrest in MKN1 cells. PROTAC CDK2 Degrader-2 achieves tumor stasis in HCC1569 (CCNE1-amplified) xenograft models. PROTAC CDK2 Degrader-2 can be used for the study of CCNE1-amplified cancers. | ||||||||||||||||||||
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