3031476-73-7
Chemical Structure
TK-129
- CAS No.: 3031476-73-7
- Formula:C15H23N5O2
- Molecular Weight:305.38
IUPAC Name: (R)-1-cyclopropyl-3-(1-(5-isopropyl-1H-pyrazole-3-carbonyl)pyrrolidin-3-yl)urea
InChIKey: WNSMPEBHTSITSG-LLVKDONJSA-N
SMILES: O=C(N[C@H]1CN(C(C2=NNC(C(C)C)=C2)=O)CC1)NC3CC3
Biological Activity: TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease[1].
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TK-129 | ≥98.0% | TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease. | ||||||||||||||||||||
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