3031812-65-1
3031812-65-1
Chemical Structure
EGFR-IN-3
- CAS No.: 3031812-65-1
- Formula:C24H18F4N6O2S
- Molecular Weight:530.50
IUPAC Name: 2-((2-((4-(3-fluorobenzamido)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-N-methylthiophene-3-carboxamide
InChIKey: MQLUFPGAAPEIPX-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC2=NC(NC3=CC=C(NC(C4=CC=CC(F)=C4)=O)C=C3)=NC=C2C(F)(F)F)SC=C1)NC
Biological Activity: EGFR-IN-3 (Compound 4c) is a potent EGFR inhibitor with an IC50 of 0.32 µM against EGFRwt-TK. EGFR-IN-3 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].
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EGFR-IN-3 | EGFR-IN-3 (Compound 4c) is a potent EGFR inhibitor with an IC50 of 0.32 µM against EGFRwt-TK. EGFR-IN-3 shows cytotoxic activity against cancer cell lines and induces apoptosis. | |||||||||||||||||||||
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