3032441-59-8
Chemical Structure
HJ445A
- CAS No.: 3032441-59-8
- Formula:C24H27N7O2
- Molecular Weight:445.52
InChIKey: URMOEUMTLANRDL-UHFFFAOYSA-N
SMILES: CCC1=NN(C2=CC=CC(C(NCCCCN3N=CC=N3)=O)=C2)C(C4=CC=C(C=C4)OC)=N1
Biological Activity: HJ445A is an orally active myoferlin (MYOF) inhibitor with a Kd value of 0.17 μM against human targets. HJ445A directly binds to the MYOF-C2D domain to stabilize the MYOF protein, thereby regulating vesicle trafficking, cell proliferation, colony formation, migration and apoptosis processes in cancer cells, and exhibits anti-tumor efficacy. HJ445A can be used in gastric cancer-related research[1][2].
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HJ445A | 98.02% | HJ445A is an orally active myoferlin (MYOF) inhibitor with a Kd value of 0.17 μM against human targets. HJ445A directly binds to the MYOF-C2D domain to stabilize the MYOF protein, thereby regulating vesicle trafficking, cell proliferation, colony formation, migration and apoptosis processes in cancer cells, and exhibits anti-tumor efficacy. HJ445A can be used in gastric cancer-related research. | ||||||||||||||||||||
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- [1]. Gullo C, et al. Focal adhesion assembly and cell migration require myoferlin in PDAC cell lines. Sci Rep. 2025 Nov 28;15(1):42797. [Content Brief]
- [2]. Gu H, et al. Discovery of a Highly Potent and Selective MYOF Inhibitor with Improved Water Solubility for the Treatment of Gastric Cancer. J Med Chem. 2023 Dec 28;66(24):16917-16938. [Content Brief]
Keywords
