3034560-21-6
3034560-21-6
Chemical Structure
RAGE406R
- CAS No.: 3034560-21-6
- Formula:C25H24N4O2
- Molecular Weight:412.48
InChIKey: MUVCLMZDXXUHRB-JOCHJYFZSA-N
SMILES: N#CC1=CC=C2C(CN3CCOCC3)=CC(C4=CC=C(C=C4)[C@H]5CCC(N5)=O)=NC2=C1
Biological Activity: RAGE406R is an orally active RAGE-DIAPH1 interaction antagonist. RAGE406R can bind to ctRAGE and prevent the formation of the RAGE-DIAPH1 complex and inhibit its interaction. RAGE406R can reduce the expression of CCL2, TNF, and IL-6 in THP1 cells. RAGE406R suppresses delayed-type hypersensitivity in T2D mice. RAGE406R can be used for the study of diabetes[1].
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RAGE406R | RAGE406R is an orally active RAGE-DIAPH1 interaction antagonist. RAGE406R can bind to ctRAGE and prevent the formation of the RAGE-DIAPH1 complex and inhibit its interaction. RAGE406R can reduce the expression of CCL2, TNF, and IL-6 in THP1 cells. RAGE406R suppresses delayed-type hypersensitivity in T2D mice. RAGE406R can be used for the study of diabetes. | |||||||||||||||||||||
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