3037514-35-2
Chemical Structure
BD-7148
- CAS No.: 3037514-35-2
- Formula:C37H30N8O5S
- Molecular Weight:698.75
InChIKey: JTXHXYXYGGEYBL-UHFFFAOYSA-N
SMILES: O=C1C2=CC=CC(N3CC(C3)N4N=CC(C#CC5=C(CC6=CC=CC=C6)C(COCC7=NN=C(C)N87)=C8S5)=C4)=C2C(N1C9C(NC(CC9)=O)=O)=O
Biological Activity: BD-7148 is a potent, highly selective BRD4 PROTAC degrader with a DC50 of 0.9 nM. BD-7148 binds to recombinant human BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1 and BRD4-BD2 domain proteins, with Kd values ranging from 26 nM to 240 nM, and shows no binding preference for BRD4 domains over BRD2 or BRD3 domains. BD-7148 inhibits the growth of leukemia and breast cancer cells. BD-7148 can be used in the research of leukemia and breast cancer[1].
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BD-7148 | BD-7148 is a potent, highly selective BRD4 PROTAC degrader with a DC50 of 0.9 nM. BD-7148 binds to recombinant human BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1 and BRD4-BD2 domain proteins, with Kd values ranging from 26 nM to 240 nM, and shows no binding preference for BRD4 domains over BRD2 or BRD3 domains. BD-7148 inhibits the growth of leukemia and breast cancer cells. BD-7148 can be used in the research of leukemia and breast cancer. | |||||||||||||||||||||
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