303969-88-2
303969-88-2
Chemical Structure
PRMT5-MTA-IN-7
- CAS No.: 303969-88-2
- Formula:C17H20N4O4S
- Molecular Weight:376.43
InChIKey: PSHDRRNFRPMGHA-UHFFFAOYSA-N
SMILES: CC(C=C1)=CC=C1CN2C(SCC(O)CO)=NC3=C2C(NC(N3C)=O)=O
Biological Activity: PRMT5-MTA-IN-7 (Compound 14) is a selective PRMT5-MTA inhibitor. PRMT5-MTA-IN-7 exhibits KD values of PRMT5-MTA-IN-7 for PRMT5-MTA and PRMT5-SAM of 236 nM and 2.84 μM respectively, and the IC50 values of 4.08 and 13.6 μM respectively. PRMT5-MTA-IN-7 can selectively inhibit the proliferation of MTAP-deficient cancer cells. PRMT5-MTA-IN-7 can be used for the study of colon cancer[1].
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PRMT5-MTA-IN-7 | PRMT5-MTA-IN-7 (Compound 14) is a selective PRMT5-MTA inhibitor. PRMT5-MTA-IN-7 exhibits KD values of PRMT5-MTA-IN-7 for PRMT5-MTA and PRMT5-SAM of 236 nM and 2.84 μM respectively, and the IC50 values of 4.08 and 13.6 μM respectively. PRMT5-MTA-IN-7 can selectively inhibit the proliferation of MTAP-deficient cancer cells. PRMT5-MTA-IN-7 can be used for the study of colon cancer. | |||||||||||||||||||||
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Keywords
