3052544-28-9
Chemical Structure
GRPR antagonist-1
- CAS No.: 3052544-28-9
- Formula:C29H33F3N4O4
- Molecular Weight:558.59
IUPAC Name: tert-butyl 4-((2-(4-(trifluoromethyl)phenyl)acetyl)-L-tryptophyl)piperazine-1-carboxylate
InChIKey: NIIBAULZUYBDEQ-DEOSSOPVSA-N
SMILES: CC(C)(OC(N1CCN(CC1)C([C@H](CC2=CNC3=C2C=CC=C3)NC(CC4=CC=C(C=C4)C(F)(F)F)=O)=O)=O)C
Biological Activity: GRPR antagonist-1 is a potent gastrin releasing peptide receptor (GRPR) antagonist, having the cytotoxicity against certain cancer cells (IC50 of 4.97, 4.36 and 3.40 μM in PC3, Pan02 and HGC-27 cells, respectively). GRPR antagonist-1 inhibits HGC-27 cell viability by decreasing the Bcl-2 level and increasing the Bax level, causing apoptosis, with anticancer activity[1].
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GRPR antagonist-1 | 99.80% | GRPR antagonist-1 is a potent gastrin releasing peptide receptor (GRPR) antagonist, having the cytotoxicity against certain cancer cells (IC50 of 4.97, 4.36 and 3.40 μM in PC3, Pan02 and HGC-27 cells, respectively). GRPR antagonist-1 inhibits HGC-27 cell viability by decreasing the Bcl-2 level and increasing the Bax level, causing apoptosis, with anticancer activity. | ||||||||||||||||||||
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