3053365-82-2
3053365-82-2
Chemical Structure
ZZM-1220
- CAS No.: 3053365-82-2
- Formula:C25H29N5O3
- Molecular Weight:447.53
InChIKey: RIYCTRNTJJXYCH-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC(C2=NC3=CC(OC)=C(C=C3C(NC4CCN(CC4)C)=N2)OC)=CC=C1)=O
Biological Activity: ZZM-1220 is a histone lysine methyltransferase G9a/GLP covalent inhibitor with IC50s of of 458 nM and 924 nM, respectively. ZZM-1220 inhibits H3K9me2 in cells and significantly induces apoptosis of triple-negative breast cancer (TNBC) cells and blocks the cell cycle in the G2/M phase[1].
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ZZM-1220 | 98.74% | ZZM-1220 is a histone lysine methyltransferase G9a/GLP covalent inhibitor with IC50s of of 458 nM and 924 nM, respectively. ZZM-1220 inhibits H3K9me2 in cells and significantly induces apoptosis of triple-negative breast cancer (TNBC) cells and blocks the cell cycle in the G2/M phase. | ||||||||||||||||||||
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References
Keywords
