3053390-98-7
Chemical Structure
TRPC4/5-IN-3
- CAS No.: 3053390-98-7
- Formula:C22H23F5N4O3
- Molecular Weight:486.44
InChIKey: JJWHQRIKRLRICS-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C)C(N1CCCO)=O)N=C(C3(CCC(F)(CC3)F)F)N2CC4=CC=C(C=C4F)F
Biological Activity: TRPC4/5-IN-3 (Compound 32) is the orally active inhibitor for transient receptor potential canonical channel 4/5 (TRPC4/5) with IC50 of 3.6 nM and 5.5 nM. TRPC4/5-IN-3 inhibits hERG channel with IC50 of 6.5 µM. TRPC4/5-IN-3 exhibits good metabolic stability in human/rat/mouse liver microsomes. TRPC4/5-IN-3 exhibits antidepressant and anxiolytic activity in mouse models, exhibits good pharmacokinetic characteristics in mouse with an oral bioavailability of 87%[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TRPC4/5-IN-3 | 99.65% | TRPC4/5-IN-3 (Compound 32) is the orally active inhibitor for transient receptor potential canonical channel 4/5 (TRPC4/5) with IC50 of 3.6 nM and 5.5 nM. TRPC4/5-IN-3 inhibits hERG channel with IC50 of 6.5 µM. TRPC4/5-IN-3 exhibits good metabolic stability in human/rat/mouse liver microsomes. TRPC4/5-IN-3 exhibits antidepressant and anxiolytic activity in mouse models, exhibits good pharmacokinetic characteristics in mouse with an oral bioavailability of 87%. | ||||||||||||||||||||
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Keywords
