3054228-62-2
3054228-62-2
Chemical Structure
PRMT5-IN-33
- CAS No.: 3054228-62-2
- Formula:C25H24BrN5O3S
- Molecular Weight:554.46
InChIKey: ULTOCOVWRCTJDQ-RLTFZFDCSA-N
SMILES: BrC1=CC2=CC=C(C=C2N=C1N)CC[C@@H]3[C@H]([C@H]([C@@H](C3)NC4=C(C=NC=N4)C(C5=CSC=C5)=O)O)O
Biological Activity: PRMT5-IN-33 (compound A8) is a selective, SAM-competitve PRMT5 inhibitors with IC50 of 10.9 nM. PRMT5-IN-33 induces apoptosis and inhibits proliferation of cells Z-138 and MOLM-13. PRMT5-IN-33 exhibits an antitumor activity[1].
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PRMT5-IN-33 | PRMT5-IN-33 (compound A8) is a selective, SAM-competitve PRMT5 inhibitors with IC50 of 10.9 nM. PRMT5-IN-33 induces apoptosis and inhibits proliferation of cells Z-138 and MOLM-13. PRMT5-IN-33 exhibits an antitumor activity. | |||||||||||||||||||||
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