3056005-98-9
3056005-98-9
Chemical Structure
ALKBH1-IN-3 prodrug
- CAS No.: 3056005-98-9
- Formula:C18H18N4O4
- Molecular Weight:354.36
InChIKey: AHKNCCOBPODTQJ-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C2=NC=C(C=N2)OCC3=CC(OC)=CC=C3)N=C1)OCC
Biological Activity: ALKBH1-IN-4 prodrug (Compound 29E) is a prodrug of a DNA N6-methyladenine demethylase ALKBH1 inhibitor that significantly increases the abundance of 6mA in cells and upregulates the AMPK signaling pathway, thereby inhibiting the viability of gastric cancer cells. ALKBH1-IN-4 prodrug exhibits excellent cellular activity and favorable metabolic exposure in vivo, and holds promise for research in gastric cancer[1].
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ALKBH1-IN-3 prodrug | 99.15% | ALKBH1-IN-4 prodrug (Compound 29E) is a prodrug of a DNA N6-methyladenine demethylase ALKBH1 inhibitor that significantly increases the abundance of 6mA in cells and upregulates the AMPK signaling pathway, thereby inhibiting the viability of gastric cancer cells. ALKBH1-IN-4 prodrug exhibits excellent cellular activity and favorable metabolic exposure in vivo, and holds promise for research in gastric cancer. | ||||||||||||||||||||
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