3067466-15-0
3067466-15-0
Chemical Structure
C12-TLRa
- CAS No.: 3067466-15-0
- Formula:C46H73N5O2
- Molecular Weight:728.10
InChIKey: HIHJXHDBDZYVSP-UHFFFAOYSA-N
SMILES: NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3CC4=CC=C(CN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C=C4
Biological Activity: C12-TLRa is an ionized adjuvant lipid. C12-TLRa targets TLR7/8 receptors in endosomes. C12-TLRa enhances mRNA delivery as a structural component of LNPs. C12-TLRa enhances innate immune responses. C12-TLRa can be used for the research of SARS-CoV-2 mRNA vaccine[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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C12-TLRa | 99.71% | C12-TLRa is an ionized adjuvant lipid. C12-TLRa targets TLR7/8 receptors in endosomes. C12-TLRa enhances mRNA delivery as a structural component of LNPs. C12-TLRa enhances innate immune responses. C12-TLRa can be used for the research of SARS-CoV-2 mRNA vaccine. | ||||||||||||||||||||
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References
- [1]. Han X, et al. Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines. Nat Nanotechnol. 2023 Jun 26. [Content Brief]
- [2]. Han EL, et al. Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain. Nano Lett. 2025 Jan 15;25(2):800-810. [Content Brief]
