3079209-82-5
Chemical Structure
22-SLF
- CAS No.: 3079209-82-5
- Formula:C60H76ClN5O13S
- Molecular Weight:1142.79
InChIKey: QIIMVKWVWJLVQP-UOTTWANGSA-N
SMILES: CCC(C)(C(C(N1CCCC[C@H]1C(O[C@@H](C2=CC(OCC(NCCCOCCOCCOCCCN(C(C3=NC4=C(S3)C=CC=C4)C(NCC5=CC=CC=C5)=O)C(CCl)=O)=O)=CC=C2)CCC6=CC=C(C(OC)=C6)OC)=O)=O)=O)C
Biological Activity: 22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 (FKBP12) with a DC50 of 0.5 µM. 22-SLF interacts with C227 and C228 in FBXO22 to induce a ternary complex between FKBP12 and FBXO22, and degrades FKBP12 in a FBXO22-dependent manner. 22-SLF can be used for fundamental cancer research as a probe to study the FBXO22 degradation pathway[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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22-SLF | 95.72% | 22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 (FKBP12) with a DC50 of 0.5 µM. 22-SLF interacts with C227 and C228 in FBXO22 to induce a ternary complex between FKBP12 and FBXO22, and degrades FKBP12 in a FBXO22-dependent manner. 22-SLF can be used for fundamental cancer research as a probe to study the FBXO22 degradation pathway. | ||||||||||||||||||||
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