3080487-43-7
3080487-43-7
Chemical Structure
PROTAC FGFR2 degrader 2
- CAS No.: 3080487-43-7
- Formula:C40H39Cl2N9O6
- Molecular Weight:812.70
InChIKey: DDHPDOGCZLIDPA-WPRGIUPFSA-N
SMILES: O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC(NCCCCCC(NCCN4N=CC(/C=C/C5=NNC6=CC=C(O[C@H](C)C7=C(Cl)C=NC=C7Cl)C=C56)=C4)=O)=CC=C31)=O
Biological Activity: FGFR2 degrader 1 (compound 28E) is a selectively PROTACS degrader of FGFR2, with the DC50 of 0.645 nM. FGFR2 plays an important role in cancer research (Pink: ligand of target protein; (HY-13304) black: linker; blue: ligand of E3 ligase)[1].
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PROTAC FGFR2 degrader 2 | FGFR2 degrader 1 (compound 28E) is a selectively PROTACS degrader of FGFR2, with the DC50 of 0.645 nM. FGFR2 plays an important role in cancer research (Pink: ligand of target protein; (HY-13304) black: linker; blue: ligand of E3 ligase). | |||||||||||||||||||||
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References
Keywords
