3093582-13-6
3093582-13-6
Chemical Structure
PROTAC AURKA degrader 2
- CAS No.: 3093582-13-6
- Formula:C50H50ClFN8O11
- Molecular Weight:993.43
InChIKey: RASMETYCOSKIGA-UHFFFAOYSA-N
SMILES: COC1=C(C=CC(NC2=NC=C3CN=C(C4=C(C3=N2)C=CC(Cl)=C4)C5=C(C=CC=C5F)OC)=C1)C(NCCOCCOCCOCCOCCNC6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=O
Biological Activity: PROTAC AURKA degrader 2 (compound D) is a potent and selective PROTAC AURKA degrader with an IC50 of 3.58 nM. PROTAC AURKA degrader 2 exhibits 21.6-fold selectivity for AURKA over AURKB (IC50 = 77.2 nM). PROTAC AURKA degrader 2 specifically depletes AURKA on the mitotic spindle[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PROTAC AURKA degrader 2 | 98.36% | PROTAC AURKA degrader 2 (compound D) is a potent and selective PROTAC AURKA degrader with an IC50 of 3.58 nM. PROTAC AURKA degrader 2 exhibits 21.6-fold selectivity for AURKA over AURKB (IC50 = 77.2 nM). PROTAC AURKA degrader 2 specifically depletes AURKA on the mitotic spindle. | ||||||||||||||||||||
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