3093582-13-6

PROTAC AURKA degrader 2 Chemical Structure
3093582-13-6

Chemical Structure

PROTAC AURKA degrader 2

  • CAS No.: 3093582-13-6
  • Formula:C50H50ClFN8O11
  • Molecular Weight:993.43

InChIKey: RASMETYCOSKIGA-UHFFFAOYSA-N

SMILES: COC1=C(C=CC(NC2=NC=C3CN=C(C4=C(C3=N2)C=CC(Cl)=C4)C5=C(C=CC=C5F)OC)=C1)C(NCCOCCOCCOCCOCCNC6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=O

Biological Activity: PROTAC AURKA degrader 2 (compound D) is a potent and selective PROTAC AURKA degrader with an IC50 of 3.58 nM. PROTAC AURKA degrader 2 exhibits 21.6-fold selectivity for AURKA over AURKB (IC50 = 77.2 nM). PROTAC AURKA degrader 2 specifically depletes AURKA on the mitotic spindle[1].

Cat. No. Product Name Purity Description Pricing
HY-180132 		PROTAC AURKA degrader 2 98.36% PROTAC AURKA degrader 2 (compound D) is a potent and selective PROTAC AURKA degrader with an IC50 of 3.58 nM. PROTAC AURKA degrader 2 exhibits 21.6-fold selectivity for AURKA over AURKB (IC50 = 77.2 nM). PROTAC AURKA degrader 2 specifically depletes AURKA on the mitotic spindle.
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