3095277-20-3
Chemical Structure
WRN degrader-1
- CAS No.: 3095277-20-3
- Formula:C37H44F3N5O5S
- Molecular Weight:727.84
InChIKey: AUAWJFOFPSNGDA-KGGVVWLGSA-N
SMILES: O=C(NCCCCCOC1=CC=C(C2=NC(S(=O)(NCC(NC3=CC=C(C)C=C3)=O)=O)=NC(C(F)(F)F)=C2)C=C1)CC45C[C@H](C6)C[C@@H](C5)C[C@H]6C4
Biological Activity: WRN degrader-1 is a selective WRN degrader derived from H3B-219. WRN degrader-1 contains a proximity-activated sulfonamide pyrimidine warhead and an adamantane hydrophobic tag, covalently modifies WRN helicase, and potently degrades WRN via the ubiquitin-proteasome pathway. WRN degrader-1 degrades WRN in MSI-H and MSS cells. WRN degrader-1 induces apoptosis, cell cycle arrest, and DNA damage, and exerts WRN-dependent antiproliferative activity. WRN degrader-1 can be used in cancer-related research[1].
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WRN degrader-1 | WRN degrader-1 is a selective WRN degrader derived from H3B-219. WRN degrader-1 contains a proximity-activated sulfonamide pyrimidine warhead and an adamantane hydrophobic tag, covalently modifies WRN helicase, and potently degrades WRN via the ubiquitin-proteasome pathway. WRN degrader-1 degrades WRN in MSI-H and MSS cells. WRN degrader-1 induces apoptosis, cell cycle arrest, and DNA damage, and exerts WRN-dependent antiproliferative activity. WRN degrader-1 can be used in cancer-related research. | |||||||||||||||||||||
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