3096805-18-1
3096805-18-1
Chemical Structure
ZJCK-6-46
- CAS No.: 3096805-18-1
- Formula:C24H21N5O
- Molecular Weight:395.46
InChIKey: MNVPCONHWCXDES-JOCHJYFZSA-N
SMILES: CC1=NC2=C(C=C1)C(C3=CC4=C(C=C3)N=CN=C4N[C@@H](C5=CC=CC=C5)CO)=CN2
Biological Activity: ZJCK-6-46 (32) is a potential and orally activeDYRK1A inhibitor (IC50 = 0.68 nM) with high BBB permeability (CNS+). ZJCK-6-46 (32) reduces tau phosphorylation. ZJCK-6-46 (32) ameliorates cognitive dysfunction by obviously reducing the expression of phosphorylated tau and neuronal loss in vivo[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
ZJCK-6-46 | 99.06% | ZJCK-6-46 (32) is a potential and orally activeDYRK1A inhibitor (IC50 = 0.68 nM) with high BBB permeability (CNS+). ZJCK-6-46 (32) reduces tau phosphorylation. ZJCK-6-46 (32) ameliorates cognitive dysfunction by obviously reducing the expression of phosphorylated tau and neuronal loss in vivo. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
