3098827-88-1
3098827-88-1
Chemical Structure
NLRP3-IN-60
- CAS No.: 3098827-88-1
- Formula:C23H24F2N4O4S
- Molecular Weight:490.52
InChIKey: ITMGDDOSMDGHTK-UHFFFAOYSA-N
SMILES: FC1=NN2C=C1S(=O)(NC(CC3=C(C4=CC(OCC2(C)C)=NC=C4)C=CC(F)=C3C(C)C)=O)=O
Biological Activity: NLRP3-IN-60 (Compound 39) is the orally active inhibitor for NLRP3. NLRP3-IN-60 inhibits pyroptosis with an IC50 of 13 nM in THP-1 cell. NLRP3-IN-60 inhibits IL-1β release with an IC50 of 225 nM in human whole blood[1].
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NLRP3-IN-60 | NLRP3-IN-60 (Compound 39) is the orally active inhibitor for NLRP3. NLRP3-IN-60 inhibits pyroptosis with an IC50 of 13 nM in THP-1 cell. NLRP3-IN-60 inhibits IL-1β release with an IC50 of 225 nM in human whole blood. | |||||||||||||||||||||
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