3098980-02-7
Chemical Structure
Skp2 inhibitor 3
- CAS No.: 3098980-02-7
- Formula:C21H19BrN4O2S
- Molecular Weight:471.37
InChIKey: QJKCFTBHTCVMGO-UHFFFAOYSA-N
SMILES: COC1=CC=C(C2=CC(C)=NC3=NC(SCC4=CC=C(Br)C=C4)=NN32)C(OC)=C1
Biological Activity: Skp2 inhibitor 3 is an orally active inhibitor of the Skp2-Cks1 complex, with an IC50 of 4.86 μM. Skp2 inhibitor 3 reduces Skp2 protein expression while upregulating the expression of p21 and p27. Skp2 inhibitor 3 inhibits colony formation and migration of cancer cells, and induces cell cycle arrest at the S phase. Skp2 inhibitor 3 suppresses tumor growth in xenograft mice. Skp2 inhibitor 3 can be used in the research of gastric cancer and prostate cancer[1].
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Skp2 inhibitor 3 | 98.07% | Skp2 inhibitor 3 is an orally active inhibitor of the Skp2-Cks1 complex, with an IC50 of 4.86 μM. Skp2 inhibitor 3 reduces Skp2 protein expression while upregulating the expression of p21 and p27. Skp2 inhibitor 3 inhibits colony formation and migration of cancer cells, and induces cell cycle arrest at the S phase. Skp2 inhibitor 3 suppresses tumor growth in xenograft mice. Skp2 inhibitor 3 can be used in the research of gastric cancer and prostate cancer. | ||||||||||||||||||||
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Keywords
