3101978-77-9
3101978-77-9
Chemical Structure
KRAS-IN-65
- CAS No.: 3101978-77-9
- Formula:C32H35ClF2N8O3
- Molecular Weight:653.12
InChIKey: BZVKBSCGOGFHHJ-SNQLIDMXSA-N
SMILES: C[C@@]12CCCN(C3=NC(OC[C@@]45CCCN4C[C@@H](C5)F)=NC6=C3C=NC(C7=C(C(Cl)=CC8=C7C=NN8)CCCOC(N2)=O)=C6F)C1
Biological Activity: KRAS-IN-65 is an orally active KRAS inhibitor. KRAS-IN-65 inhibits KRAS G12D/G12V signaling with IC50 values of 20 nM and 5 nM, respectively. KRAS-IN-65 exhibits reduced glucuronidation and intestinal stability. KRAS-IN-65 produces limited tumor growth inhibition in xenograft models. KRAS-IN-65 can be used for cancer-related research, such as non-small cell lung cancer and colorectal cancer[1].
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KRAS-IN-65 | KRAS-IN-65 is an orally active KRAS inhibitor. KRAS-IN-65 inhibits KRAS G12D/G12V signaling with IC50 values of 20 nM and 5 nM, respectively. KRAS-IN-65 exhibits reduced glucuronidation and intestinal stability. KRAS-IN-65 produces limited tumor growth inhibition in xenograft models. KRAS-IN-65 can be used for cancer-related research, such as non-small cell lung cancer and colorectal cancer. | |||||||||||||||||||||
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