3102894-57-2
Chemical Structure
GPX4-IN-19
- CAS No.: 3102894-57-2
- Formula:C19H19ClFNO5
- Molecular Weight:395.81
InChIKey: OJPCKRGUPMMORU-UHFFFAOYSA-N
SMILES: COC1=CC(N(C(CCl)=O)CC2=CC3=C(OCCO3)C=C2)=CC(OC)=C1F
Biological Activity: GPX4-IN-19 is an effective GPX4 inhibitor (IC50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4. GPX4-IN-19 shows strong anti-proliferative activity with high ferroptosis selectivity. GPX4-IN-19 causes intracellular Fe2+ accumulation, leading to increased levels of lipid peroxides (LPOs) and reactive oxygen species (ROS), which induces ferroptosis and subsequently results in DNA damage. GPX4-IN-19 can be used for the study of Triple-Negative Breast Cancer (TNBC)[1].
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GPX4-IN-19 | 99.45% | GPX4-IN-19 is an effective GPX4 inhibitor (IC50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4. GPX4-IN-19 shows strong anti-proliferative activity with high ferroptosis selectivity. GPX4-IN-19 causes intracellular Fe2+ accumulation, leading to increased levels of lipid peroxides (LPOs) and reactive oxygen species (ROS), which induces ferroptosis and subsequently results in DNA damage. GPX4-IN-19 can be used for the study of Triple-Negative Breast Cancer (TNBC). | ||||||||||||||||||||
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