3103731-64-9
3103731-64-9
Chemical Structure
NEK7-IN-2
- CAS No.: 3103731-64-9
- Formula:C27H28F4N6O2
- Molecular Weight:544.54
InChIKey: BOSHHNIIJAEIJN-UHFFFAOYSA-N
SMILES: FC1=C(NC(NC2=CC(C(F)(F)F)=C(CN3CCN(C)CC3)C=C2)=O)C=CC(C4=CC=C(NC(C)=O)N=C4)=C1
Biological Activity: NEK7-IN-2 is a NEK7 inhibitor. NEK7-IN-2 increases the thermal stability of NEK7, disrupts the NEK7-NLRP3 interaction, inhibits NLRP3 inflammasome assembly, and suppresses the release of IL-1β (with an IC50 of 0.048 μM against IL-1β). NEK7-IN-2 can be used for the research of inflammatory diseases[1].
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NEK7-IN-2 | NEK7-IN-2 is a NEK7 inhibitor. NEK7-IN-2 increases the thermal stability of NEK7, disrupts the NEK7-NLRP3 interaction, inhibits NLRP3 inflammasome assembly, and suppresses the release of IL-1β (with an IC50 of 0.048 μM against IL-1β). NEK7-IN-2 can be used for the research of inflammatory diseases. | |||||||||||||||||||||
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