3106086-17-0
Chemical Structure
ZS34
- CAS No.: 3106086-17-0
- Formula:C18H14ClN3O2
- Molecular Weight:339.78
InChIKey: WHVVEMNZILBQCX-UHFFFAOYSA-N
SMILES: O=C1N(C2=C(C(NC)=N1)C3=C(C(Cl)=C2)C=CO3)C4=CC=CC=C4C
Biological Activity: ZS34 is a potent, orally active, and selective MAT2A inhibitor with an IC50 of 13.7 nM, displaying minimal hERG and UGT1A1 liabilities. ZS34 selectively suppresses the growth of methylthioadenosine phosphorylase (MTAP)-deficient cancer cells by inhibiting SAM synthesis, reducing SDMA levels, and inducing DNA damage. ZS34 exhibits antitumor efficacy in a HCT116 MTAP-/- xenograft mouse model. ZS34 can be used for the research of MTAP-deficient cancer[1].
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ZS34 | ZS34 is a potent, orally active, and selective MAT2A inhibitor with an IC50 of 13.7 nM, displaying minimal hERG and UGT1A1 liabilities. ZS34 selectively suppresses the growth of methylthioadenosine phosphorylase (MTAP)-deficient cancer cells by inhibiting SAM synthesis, reducing SDMA levels, and inducing DNA damage. ZS34 exhibits antitumor efficacy in a HCT116 MTAP-/- xenograft mouse model. ZS34 can be used for the research of MTAP-deficient cancer. | |||||||||||||||||||||
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