3106183-96-1
Chemical Structure
TIPARP-IN-1
- CAS No.: 3106183-96-1
- Formula:C22H23F6N5O2
- Molecular Weight:503.44
InChIKey: QPPRMYWGJMMFHW-NFAWXSAZSA-N
SMILES: O=C([C@H]1C[C@@H](CC2=CNC(C(C(F)(F)F)=C2)=O)C1)N(C[C@H]3C)CCN3C4=NC=C(C(F)(F)F)C=N4
Biological Activity: TIPARP-IN-1 (Compound 15) is a selective PARP7 (TIPARP) (2,3,7,8-Tetrachlorodiben-zo-p-dioxin(TCDD)-inducible PARP) inhibitor with an IC50 of 2.15 nM. TIPARP-IN-1 can restore IFN signaling pathway in tumors by inhibiting TIPARP. TIPARP-IN-1 selectively activates the anti-tumor immune response in the tumor microenvironment and avoids the production of systemic cytokines. TIPARP-IN-1 can be used for research of head and neck squamous cell carcinoma[1].
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TIPARP-IN-1 | TIPARP-IN-1 (Compound 15) is a selective PARP7 (TIPARP) (2,3,7,8-Tetrachlorodiben-zo-p-dioxin(TCDD)-inducible PARP) inhibitor with an IC50 of 2.15 nM. TIPARP-IN-1 can restore IFN signaling pathway in tumors by inhibiting TIPARP. TIPARP-IN-1 selectively activates the anti-tumor immune response in the tumor microenvironment and avoids the production of systemic cytokines. TIPARP-IN-1 can be used for research of head and neck squamous cell carcinoma. | |||||||||||||||||||||
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Keywords
