3108318-77-7
Chemical Structure
JAK2-IN-18
- CAS No.: 3108318-77-7
- Formula:C37H36N8O4
- Molecular Weight:656.73
InChIKey: INJXKZVMNQNKPR-UHFFFAOYSA-N
SMILES: COC(C(NC1=CC(NC(C2CC2)=O)=NN3C1=NC=C3)=CC=C4)=C4C5=CC(C6(CC6)C7)=C(C=C5)C(N7CC8=CC=CC(C(N(C)C)=O)=N8)=O
Biological Activity: JAK2-IN-18 (Compound example1) is a selective JAK2 inhibitor. JAK2-IN-18 can inhibit JAK-STAT signaling and shows an IC50 of <100 nM for pSTAT5 in HEL9217 cells. JAK2-IN-18 can inhibit the proliferation of abnormally proliferating myeloid cells and can be used for the research of myeloproliferative disorders, such as essential thrombocythemia[1].
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JAK2-IN-18 | JAK2-IN-18 (Compound example1) is a selective JAK2 inhibitor. JAK2-IN-18 can inhibit JAK-STAT signaling and shows an IC50 of <100 nM for pSTAT5 in HEL9217 cells. JAK2-IN-18 can inhibit the proliferation of abnormally proliferating myeloid cells and can be used for the research of myeloproliferative disorders, such as essential thrombocythemia. | |||||||||||||||||||||
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Keywords
