3113779-38-4
Chemical Structure
DNA/TOP2A-IN-1
- CAS No.: 3113779-38-4
- Formula:C32H29N5O4
- Molecular Weight:547.60
IUPAC Name: N-((5-(4-methoxyphenoxy)-1,3-dimethyl-1H-pyrazol-4-yl)methyl)-1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxamide
InChIKey: LIDMGGZVGODHAG-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)OC2=C(C(C)=NN2C)CNC(C3=CC4=C(C(C5=CC=C(C=C5)OC)=N3)NC6=CC=CC=C64)=O
Biological Activity: DNA/TOP2A-IN-1 is an inhibitor of DNA and TOP2A. DNA/TOP2A-IN-1 selectively binds to TOP2A, not TOP2B, and interacts with DNA and TOP2A to form a stable DM1-TOP2A-DNA ternary complex. DNA/TOP2A-IN-1 induces DNA damage, increases reactive oxygen species (ROS) and triggers apoptosis in triple-negative breast cancer (TNBC) cells. DNA/TOP2A-IN-1 disrupts microtubule distribution and induces cell cycle arrest. DNA/TOP2A-IN-1 shows strong antiproliferative activity and inhibits cell migration. DNA/TOP2A-IN-1 inhibits tumor growth and can be used for TNBC research[1].
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DNA/TOP2A-IN-1 | DNA/TOP2A-IN-1 is an inhibitor of DNA and TOP2A. DNA/TOP2A-IN-1 selectively binds to TOP2A, not TOP2B, and interacts with DNA and TOP2A to form a stable DM1-TOP2A-DNA ternary complex. DNA/TOP2A-IN-1 induces DNA damage, increases reactive oxygen species (ROS) and triggers apoptosis in triple-negative breast cancer (TNBC) cells. DNA/TOP2A-IN-1 disrupts microtubule distribution and induces cell cycle arrest. DNA/TOP2A-IN-1 shows strong antiproliferative activity and inhibits cell migration. DNA/TOP2A-IN-1 inhibits tumor growth and can be used for TNBC research. | |||||||||||||||||||||
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