3114105-24-4
Chemical Structure
TREM2 agonist-5
- CAS No.: 3114105-24-4
- Formula:C24H21ClFN5O
- Molecular Weight:449.91
IUPAC Name: 5-(4-chloro-2-fluorophenyl)-2,3-dimethyl-7-(6-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-2H-pyran-4-yl)pyrido[3,4-b]pyrazine
InChIKey: KYSVLVXAWUSYBH-UHFFFAOYSA-N
SMILES: CN1N=CC(C2C=C(C3=NC(C4=CC=C(Cl)C=C4F)=C(N=C(C)C(C)=N5)C5=C3)CCO2)=C1
Biological Activity: TREM2 agonist-5 is the microglial lipid-sensing receptor (TREM2) agonist with a Kd of 71.36 μM. TREM2 agonist-5 is a racemic structural analog of the TREM2 agonist VG-3927 and exhibits superior microglial phagocytosis and activates TREM2 signaling in HEK293-hTREM2/DAP12 cells. TREM2 agonist-5 displays a superior in vitro pharmacokinetic profile to VG-3927. TREM2 agonist-5 can used for the study of Alzheimer’s disease[1].
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TREM2 agonist-5 | 99.61% | TREM2 agonist-5 is the microglial lipid-sensing receptor (TREM2) agonist with a Kd of 71.36 μM. TREM2 agonist-5 is a racemic structural analog of the TREM2 agonist VG-3927 and exhibits superior microglial phagocytosis and activates TREM2 signaling in HEK293-hTREM2/DAP12 cells. TREM2 agonist-5 displays a superior in vitro pharmacokinetic profile to VG-3927. TREM2 agonist-5 can used for the study of Alzheimer’s disease. | ||||||||||||||||||||
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