3115114-11-6
Chemical Structure
TFAP4/Wnt/β-catenin-IN-1
- CAS No.: 3115114-11-6
- Formula:C27H33BrN2O3
- Molecular Weight:513.47
InChIKey: QMWJGZMIWCIIRM-KPMKUPEJSA-N
SMILES: BrC1=CC=C(C([H])C(C=C2/C=C/[C@H]3[C@@](CC[C@@H](O)[C@]4(CO)C)(C)C4CC=C3C)=NNC2=O)C=C1
Biological Activity: TFAP4/Wnt/β-catenin-IN-1 (Compound A61) is an orally active TFAP4/Wnt/β-catenin inhibitor. TFAP4/Wnt/β-catenin-IN-1 has significant anticancer activity against a variety of cancer cells (such as gastric cancer, lung cancer, breast cancer, etc.), and has the strongest anticancer activity against MGC-803 gastric cancer cells (IC50: 3.92 μM). TFAP4/Wnt/β-catenin-IN-1 induces apoptosis and cell cycle arrest (S phase) in cancer cells by inhibiting the TFAP4/Wnt/β-catenin signaling pathway. TFAP4/Wnt/β-catenin-IN-1 can be used in the study of gastric cancer[1].
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TFAP4/Wnt/β-catenin-IN-1 | 95.39% | TFAP4/Wnt/β-catenin-IN-1 (Compound A61) is an orally active TFAP4/Wnt/β-catenin inhibitor. TFAP4/Wnt/β-catenin-IN-1 has significant anticancer activity against a variety of cancer cells (such as gastric cancer, lung cancer, breast cancer, etc.), and has the strongest anticancer activity against MGC-803 gastric cancer cells (IC50: 3.92 μM). TFAP4/Wnt/β-catenin-IN-1 induces apoptosis and cell cycle arrest (S phase) in cancer cells by inhibiting the TFAP4/Wnt/β-catenin signaling pathway. TFAP4/Wnt/β-catenin-IN-1 can be used in the study of gastric cancer. | ||||||||||||||||||||
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