3115216-45-7
Chemical Structure
EGFR-IN-213
- CAS No.: 3115216-45-7
- Formula:C35H43Cl3N9O2P
- Molecular Weight:759.11
InChIKey: CXIZWGKRHNRSMX-UHFFFAOYSA-N
SMILES: CP(C)(C1=CC=CC=C1NC2=NC(NC3=CC(NCC4=C(Cl)C(Cl)=NC=C4)=C(N5CCC(N6CCN(C)CC6)CC5)C=C3OC)=NC=C2Cl)=O
Biological Activity: EGFR-IN-213 is a selective inhibitor of EGFRL858R/T790M/C797S with a human IC50 of 0.48 nM. EGFR-IN-213 acts as an antiproliferative agent, inducing apoptosis and cell cycle arrest, and inhibiting colony formation, cell migration, and tube formation. EGFR-IN-213 can be used for the research of non-small cell lung cancer, chronic myeloid leukemia, gastric cancer, prostate cancer[1].
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EGFR-IN-213 | EGFR-IN-213 is a selective inhibitor of EGFRL858R/T790M/C797S with a human IC50 of 0.48 nM. EGFR-IN-213 acts as an antiproliferative agent, inducing apoptosis and cell cycle arrest, and inhibiting colony formation, cell migration, and tube formation. EGFR-IN-213 can be used for the research of non-small cell lung cancer, chronic myeloid leukemia, gastric cancer, prostate cancer. | |||||||||||||||||||||
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Keywords
